Piraeus (Athens ) to Civitavecchia (Rome)

Of all the Cyclades Islands, Santorini is often considered the most dramatic. Once an active volcano, it was known as Stongyle, or the Round Island. In about 1500 BC, the volcano erupted with such force that the center of the island literally exploded, leaving the haunting submerged crater into which Crystal Serenity sails. The island’s small villages were preserved in the ashes and recent excavations have uncovered a fascinating view of everyday life from 3,500 years ago. Santorini’s dark landscape offsets its simple, yet refined Cycladic buildings, which glimmer in the sunlight. The rich volcanic soil is ideal for grapes and the local vines produce a cherished crop known for its “special volcanic taste.” Thíra, or Fira Town, is laid out along the edge of a cliff that partially forms the rim of the now extinct caldera. A picturesque site, it exudes charm and an atmosphere of leisure that can be attributed to the easy-going Greek lifestyle.

Today, its Old Town is alive with contemporary shops and traditional bazaars that teem with locals and visitors, surrounded by lively cafés. But this charming “old” quarter is infantile compared to one of Bodrum’s most important sites: the Mausoleum of Halicarnassus. Dating back to 350 B.C., the 140-foot white marble structure still captivates even the savviest scientists, ranking as one of the Seven Wonders of the Ancient World.

The island nation of Malta is a treasure trove of cultures. Valletta, its fortified main city, rises dramatically from the water. This “City of Knights,” a monument to the past, was founded in 1566 by the Grand Master of the Knights of St. John. Sights not to be missed include the Magisterial Palace and St. John’s Cathedral, which is lavishly decorated with the coats of arms and banners of the crusading knights. Beyond Valletta, the countryside, although austere and rocky, has a special charm. Malta provides an enduring fascination for all visitors.

Trapani is a city in western Sicily with a crescent-shaped coastline. At the western tip, offering views as far as the Aegadian Islands, is the 17th-century Torre di Ligny watchtower. It houses the Museo di Preistoria e del Mare, with archeological artifacts. North of the harbor, the Chiesa del Purgatorio church holds wooden sculptures that are paraded around the city during Easter’s Processione dei Misteri.

Venture through Civitavecchia, noted for its fine seafood and beautiful monuments. Then, travel to the Eternal City of Rome, with more than 2,500 years of history and ancient landmarks that will leave you with memories for a lifetime.